A tuned affinity-based staurosporine probe for in situ profiling of protein kinases†
Xiamin Cheng,Lin Li,Mahesh Uttamchandani,Shao Q. Yao
Chemical Communications Pub Date : 01/28/2014 00:00:00 , DOI:10.1039/C4CC00184B
Abstract
A clickable and cell-permeable affinity-based probe (AfBP) was designed from staurosporine, by incorporating an electrophilic chloroacetamide warhead to facilitate in situ proteome labeling of a range of potential kinase targets.
