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Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands†
Tomris Coban,Cameron Robertson,Sianne Schwikkard,Richard Singer,Adam LeGresley
RSC Medicinal Chemistry Pub Date : 03/26/2021 00:00:00 , DOI:10.1039/D0MD00428F
Abstract

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

Graphical abstract: Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
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