A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis†
Martyn Inman,Christopher J. Moody
Chemical Communications Pub Date : 11/22/2010 00:00:00 , DOI:10.1039/C0CC04306K
Abstract

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

Graphical abstract: A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis