Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers†,10.1039/C8CC03230K

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers†

Kazuma Murakami,Takuya Yoshioka,Shiori Horii,Mizuho Hanaki,Satohiro Midorikawa,Shinji Taniwaki,Hiroki Gunji,Ken-ichi Akagi,Taiji Kawase,Kenji Hirose,Kazuhiro Irie

Chemical Communications Pub Date : 05/23/2018 00:00:00 , DOI:10.1039/C8CC03230K

Abstract

Herein we report that a preferable inhibition of the nucleation phase of Aβ42, related to the formation of toxic oligomers, by triterpenoids from medicinal herbs originates from a salt bridge of their carboxy groups with Lys16 and 28 in Aβ42. Such a direct interaction targeting the monomer, dimer, and trimer suppressed further oligomerization. In contrast, the corresponding congeners without carboxy groups failed to do so.