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Click-chemistry approach to azacycloalkene monosulfonyl diamines: synthesis and computational analysis of the reaction mechanism†‡
Alessandro Contini,Emanuela Erba
RSC Advances Pub Date : 09/11/2012 00:00:00 , DOI:10.1039/C2RA21592F
Abstract

The cycloaddition reaction of the morpholino enamines of N-methylpiperidone and N-methyl tropinone with sulfonylazides was exploited, leading to a click-chemistry approach to uncommon azacycloalkene monosulfonyl diamines in good yields. A computational model for the key step decomposition of the triazoline intermediate was then realized by DFT calculations. The model explains the observed reaction outcome and leads to a new interpretation of the decomposition mechanism for 5-amino-1,2,3-triazolines.

Graphical abstract: Click-chemistry approach to azacycloalkene monosulfonyl diamines: synthesis and computational analysis of the reaction mechanism
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