Synthesis of β-enaminodicarbonyl derivatives in the titanium(iv) chloride-promoted reactions of β-dicarbonyl compounds with nitriles†,10.1039/C4RA05100A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis of β-enaminodicarbonyl derivatives in the titanium(iv) chloride-promoted reactions of β-dicarbonyl compounds with nitriles†

Shuchen Pei,Chenchen Xue,Li Hai,Yong Wu

RSC Advances Pub Date : 08/18/2014 00:00:00 , DOI:10.1039/C4RA05100A

Abstract

Titanium(IV) chloride selectively promoted the nucleophilic attack of ethyl acetoacetate with nitriles to give enaminoketoesters, which were valuable intermediates for the syntheses of 2,3,4-substituted heterocyclics. Moreover a plausible mechanism for this transformation was given.