Selective manipulation of steroid hydroxyl groups with boronate esters: efficient access to antigenic C-3 linked steroid–protein conjugates and steroid sulfate standards for drug detection†‡,10.1039/B610499A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Selective manipulation of steroid hydroxyl groups with boronate esters: efficient access to antigenic C-3 linked steroid–protein conjugates and steroid sulfate standards for drug detection†‡

Natasha L. Hungerford,Andrew R. McKinney,Allen M. Stenhouse,Malcolm D. McLeod

Organic & Biomolecular Chemistry Pub Date : 09/22/2006 00:00:00 , DOI:10.1039/B610499A

Abstract

The temporary protection of 17α-alkyl-5α-androstane-3β,16β,17β triols as boronate esters is an efficient method for their regioselective functionalisation. This has been applied to the synthesis of protein–steroid conjugates 7–10 suitable for the development of immunoassays targeting classes of steroids banned from competition in Australian horse racing and other sports. The synthesis of steroids sulfate conjugates 42 and 44 for use as reference standards is also reported.