[11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography†,10.1039/C6CC00895J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

[11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography†

V. N. Carroll,C. Truillet,B. Shen,R. R. Flavell,X. Shao,M. J. Evans,H. F. VanBrocklin,P. J. H. Scott,F. T. Chin,D. M. Wilson

Chemical Communications Pub Date : 03/01/2016 00:00:00 , DOI:10.1039/C6CC00895J

Abstract

Here we report the radiosynthesis of an endogenous redox pair, [¹¹C]ascorbic acid ([¹¹C]VitC) and [¹¹C]dehydroascorbic acid ([¹¹C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).