Self condensation of enamines mediated by acetylation. A novel approach to 1-(azol-5-yl)-(1E,3Z)-butadiene-4-N,N-dimethylamines†‡,10.1039/C2OB25331C

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Self condensation of enamines mediated by acetylation. A novel approach to 1-(azol-5-yl)-(1E,3Z)-butadiene-4-N,N-dimethylamines†‡

Yuri Shafran,Yuri Rozin,Tetyana Beryozkina,Sergei Zhidovinov,Oleg Eltsov,Johann Leban,Rashida Novikova,Vasiliy Bakulev

Organic & Biomolecular Chemistry Pub Date : 03/29/2012 00:00:00 , DOI:10.1039/C2OB25331C

Abstract

Novel self-condensation of 3-(azol-5-yl)-1,1-dimethylenamines has been found to form new C–C bonds leading to 2,4-(1,2,3-triazole-1,2,3-thiadiazole-3-phenylisothiazole)-(1E,3Z)-5-yl-butadiene-1-amines. The discovered reaction represents a new example of C–H functionalization in unsaturated systems and can serve an efficient synthetic approach to rational design of new 2,4-(diazole-5-yl)-dieneamines.