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Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives
Organic & Biomolecular Chemistry Pub Date : 09/17/2013 00:00:00 , DOI:10.1039/C3OB41172A
Abstract

Cope-type hydroaminations are versatile for the direct amination of alkenes, alkynes and allenes using hydroxylamines and hydrazine derivatives. These reactions occur via a concerted, 5-membered cyclic transition state that is the microscopic reverse of the Cope elimination. This article focuses on recent developments, including intermolecular variants, directed reactions, and asymmetric variants using aldehydes as tethering catalysts, and their applications in target-oriented synthesis.

Graphical abstract: Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives
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