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Regioselective asymmetric stereoablative O-alkylation of α-nitrophosphonates via o-azaxylylene intermediates generated in situ from 3-bromooxindoles†
Xiaohua Xie,Linhai Jing,Dabin Qin,Wujun He,Song Wu,Lunqiang Jin,Gan Luo
RSC Advances Pub Date : 02/11/2014 00:00:00 , DOI:10.1039/C3RA47100D
Abstract

Enantioselective O-alkylation of α-nitrophosphonates was reported for the first time. A series of optically active 3,3-disubstituted oxindoles was prepared via a less exploited organocatalyzed stereoablative reaction of 3-bromooxindoles.

Graphical abstract: Regioselective asymmetric stereoablative O-alkylation of α-nitrophosphonates via o-azaxylylene intermediates generated in situ from 3-bromooxindoles
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