Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles†,10.1039/C4NR05638H

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles†

Jasmin A. Holz,Xiaomin Liu,Youlin Zhang,Langping Tu,Xianggui Kong,Bram Priem,Annemarie Nadort,Saskia A. G. Lambrechts,Maurice C. G. Aalders,Wybren Jan Buma,Yichun Liu,Hong Zhang

Nanoscale Pub Date : 11/03/2014 00:00:00 , DOI:10.1039/C4NR05638H

Abstract

In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).