Temperature, pH and H-bond synergism for peptide bond formation: synthesis of sequence specific tetra- and penta-peptides without using coupling reagent†,10.1039/C4RA06187J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Temperature, pH and H-bond synergism for peptide bond formation: synthesis of sequence specific tetra- and penta-peptides without using coupling reagent†

Palwinder Singh,Amrinder Singh,Sukhmeet Kaur,Venus Singh Mithu,Manpreet S. Bhatti

RSC Advances Pub Date : 08/04/2014 00:00:00 , DOI:10.1039/C4RA06187J

Abstract

A reaction temperature of 120 °C, pH of 5.0 and reaction time of 6 h were chosen as the best conditions for the condensation of two nonactivated amino acids to form a peptide bond. Role of H-bond in these reactions was anticipated. The method was validated by procuring sequence specific tetrapeptides and pentapeptides without any disturbance to their chirality.