Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors†,10.1039/C3OB41395K

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors†

Jonathan G. Rudick,Meg M. Laakso,Ashley C. Schloss,William F. DeGrado

Organic & Biomolecular Chemistry Pub Date : 09/17/2013 00:00:00 , DOI:10.1039/C3OB41395K

Abstract

Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO₃DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified.