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Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models†
Nathalie M. Pinkerton,Céline Frongia,Valérie Lobjois,Brian K. Wilson,Matthew J. Bruzek,Robert K. Prud'homme,John Anthony,Frédéric Bolze,Stefan Chassaing
RSC Advances Pub Date : 07/06/2016 00:00:00 , DOI:10.1039/C6RA09954H
Abstract

Biocompatible and biostable EtTP-5-loaded organic core–shell nanoparticles have been successfully evaluated for their potential as red-emitting fluorescent nanoprobes for two-photon imaging. Readily formed by Flash NanoPrecipitation, EtTP-5-based nanoprobes proved to penetrate well into multicellular spheroids and were easily imaged through several cell layers within these complex, 3D tissue models.

Graphical abstract: Red-emitting, EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models
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