Covering: Mid-2000 to 2002. Previous reviews: Nat. Prod. Rep., 2001, 18, 231–281; Nat. Prod. Rep., 2001, 18, 190–227.

This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation.