Synthesis and properties of geometrical 4-diarylmethylene analogs of the green fluorescent protein chromophore†,10.1039/C8OB00208H

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis and properties of geometrical 4-diarylmethylene analogs of the green fluorescent protein chromophore†

Masahiro Ikejiri,Haruka Kojima,Yuumi Fugono,Aki Fujisaka,Yoshiko Chihara,Kazuyuki Miyashita

Organic & Biomolecular Chemistry Pub Date : 03/14/2018 00:00:00 , DOI:10.1039/C8OB00208H

Abstract

We have developed a novel analog of the GFP chromophore: geo-DAIN. Since geo-DAIN is equipped with an E/Z-photoisomerizable geometrical diarylmethylene moiety instead of benzylidene of the GFP chromophore, different-colored reversible emissions are expected. We synthesized geo-DAIN by a condensation with methyl imidate and N-(diarylmethylene)glycinate. We found the emission from geo-DAIN to be different from that of benzylidene-type analogs; in the powder state, the E- and Z-isomers of geo-DAIN emitted different fluorescence colors.