7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes†,10.1039/B606058G

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7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes†

Takayuki Shibata,Niklaas J. Buurma,John A. Brazier,Peter Thompson,Ihtshamul Haq,David M. Williams

Chemical Communications Pub Date : 07/11/2006 00:00:00 , DOI:10.1039/B606058G

Abstract

Incorporation of a bicyclic cytosine analogue, 3-β-D-(2′-deoxyribofuranosyl)-7,8-dihydropyrido[2,3-d]pyrimidine, into synthetic DNA duplexes results in a greatly enhanced thermal stability (3–4 °C per modification) compared to the corresponding unmodified duplex.