Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry†,10.1039/B710348D

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Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry†

Isabel Pérez-Castro,Olga Caamaño,Franco Fernández,Marcos D. García,Carmen López,Erik De Clercq

Organic & Biomolecular Chemistry Pub Date : 10/12/2007 00:00:00 , DOI:10.1039/B710348D

Abstract

The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.