Rhodium(iii)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols†,10.1039/D0OB02323J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Rhodium(iii)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols†

Jidan Liu,Jinyuan Jiang,Zhenke Yang,Qiaohai Zeng,Jieying Zheng,Siying Zhang,Liyao Zheng,Shang-Shi Zhang,Zhao-Qing Liu

Organic & Biomolecular Chemistry Pub Date : 01/06/2021 00:00:00 , DOI:10.1039/D0OB02323J

Abstract

An efficient Rh(III)-catalyzed C–H oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols by merging tandem C–H and C–C cleavage was developed. This transformation features mild reaction conditions, high regioselectivity, and excellent functional group compatibility. The resulting β-aryl ketone derivatives can be readily transformed into 7-azaindole-containing π-extended polycyclic heteroarenes.