Synthesis of C3-alkenylated 2,3,4-trisubstituted pyrrole derivatives through cyclization of methylene isocyanides and ene–yne–ketones†,10.1039/D0NJ05253A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis of C3-alkenylated 2,3,4-trisubstituted pyrrole derivatives through cyclization of methylene isocyanides and ene–yne–ketones†

Shasha Li,Gongruixue Zeng,Xiaoqi Xing,Zhiheng Yang,Feiyun Ma,Boxia Li,Weiyan Cheng,Jiankang Zhang,Ruoyu He

New Journal of Chemistry Pub Date : 12/21/2020 00:00:00 , DOI:10.1039/D0NJ05253A

Abstract

A mild, transition-metal-free and facile C3-alkenylated 2,3,4-trisubstituted pyrrole cyclization of methylene isocyanides with ene–yne–ketones in moderate to good yields was explored. The E-alkenylated products were isolated in moderate to exclusive selectivity in most cases. The investigated compounds in this work are expected to open up for use as potential medicinal agents or precursors for post-modification.