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Robust synthesis of F-BODIPYs†
Michael Helmut Reynolds Beh,Katherine Isabelle Biehn Douglas,Kelsey Taylor Elver House,Alexandra Celeste Murphy,Jackson Scott Testemale Sinclair,Alison Thompson
Organic & Biomolecular Chemistry Pub Date : 11/24/2016 00:00:00 , DOI:10.1039/C6OB02238C
Abstract

A protocol is established for the high-yielding synthesis of F-BODIPYs involving non-anhydrous reagents and not requiring precautions to exclude moisture. This simple and robust strategy simply requires a second addition of NEt3 and BF3·OEt2, midway through the reaction period. The ratio and amounts of NEt3 and BF3·OEt2 used in each aliquot are critical to success (6 : 9 for each aliquot). The protocol can be completed using bench-dry apparatus, without need to achieve and maintain anhydrous conditions or solvents.

Graphical abstract: Robust synthesis of F-BODIPYs
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