The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess,10.1039/B003941L

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

Kaori Matoishi,Satoshi Hanzawa,Hitoshi Kakidani,Masumi Suzuki,Takeshi Sugai,Hiromichi Ohta

Chemical Communications Pub Date : 07/21/2000 00:00:00 , DOI:10.1039/B003941L

Abstract

Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [α-²H]- and [α-¹H]phenylmalonic acid in ¹H₂O and ²H₂O respectively, gave highly enantiomerically enriched (R)- and (S)-[α-²H]phenylacetic acid in quantitative yields.