A straightforward synthesis of 2-aminobenzothiazoles from Herz compounds†‡
Ana G. Neo,Rosa M. Carrillo,Carlos F. Marcos
Organic & Biomolecular Chemistry Pub Date : 04/06/2011 00:00:00 , DOI:10.1039/C1OB05398A
Abstract

2-Aminobenzothiazoles are readily synthesised from anilines, sulfur monochloride and isocyanides. The key step consists of an iodine-catalysed insertion of isocyanides into the S–S bond of hydrolysed Herz salts, with concomitant extrusion of sulfur monoxide.

Graphical abstract: A straightforward synthesis of 2-aminobenzothiazoles from Herz compounds