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Rh(i)-catalyzed decarbonylative direct C2-olefination of indoles with vinyl carboxylic acids†
Lingjuan Zhang,Ruiying Qiu,Xiao Xue,Yixiao Pan,Conghui Xu,Doudou Wang,Xinyu Wang,Lijin Xu,Huanrong Li
Chemical Communications Pub Date : 08/28/2014 00:00:00 , DOI:10.1039/C4CC06036A
Abstract

A general and efficient Rh(I)-catalyzed decarbonylative direct C2-olefination of indoles with vinyl carboxylic acids has been developed. The reaction exhibits excellent functional group tolerance, regioselectivity and stereoselectivity, giving a broad range of C2-alkenylated indoles in good to excellent yields.

Graphical abstract: Rh(i)-catalyzed decarbonylative direct C2-olefination of indoles with vinyl carboxylic acids
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