Rh(iii)-Catalyzed Csp2–Csp3 bond alkoxylation of α-indolyl alcohols via C–C σ bond cleavage†,10.1039/D1QO00194A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Rh(iii)-Catalyzed Csp2–Csp3 bond alkoxylation of α-indolyl alcohols via C–C σ bond cleavage†

Can Yang,Zhipeng Liu,Xinwei Hu,Haisheng Xie,Huanfeng Jiang,Wei Zeng

Organic Chemistry Frontiers Pub Date : 03/31/2021 00:00:00 , DOI:10.1039/D1QO00194A

Abstract

A Rh(III)-catalyzed direct Csp²–Csp³ bond alkoxylation of α-(2-indolyl)alcohols with alcohols has been reported. This transformation features a rapid C–C sigma bond/C–O single bond switch, and provides a novel approach for assembling 2-alkoxylindole skeletons. A catalytic cycle involving a β-aryl elimination process is proposed.