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Albumin-controlled stereoselective reduction of 1,3-diketones to anti-diols†
Fabio Benedetti,Federico Berti,Ivan Donati,Massimo Fregonese
Chemical Communications Pub Date : 03/15/2002 00:00:00 , DOI:10.1039/B200474G
Abstract

An unprecedented combination of high chemo- and stereoselectivity in the NaBH4 reduction of 1∶1 complexes between albumin and aromatic 1,3-diketones results in the formation of anti 1,3-diols with de up to 96%.

Graphical abstract: Albumin-controlled stereoselective reduction of 1,3-diketones to anti-diols
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