Acidic-functionalized ionic liquid as an efficient, green and reusable catalyst for hetero-Michael addition of nitrogen, sulfur and oxygen nucleophiles to α,β-unsaturated ketones†,10.1039/C1OB06346D

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Acidic-functionalized ionic liquid as an efficient, green and reusable catalyst for hetero-Michael addition of nitrogen, sulfur and oxygen nucleophiles to α,β-unsaturated ketones†

Lei Yang,Zhen Li,Chungu Xia

Organic & Biomolecular Chemistry Pub Date : 09/27/2011 00:00:00 , DOI:10.1039/C1OB06346D

Abstract

A series of acidic-functionalized ionic liquids were synthesized and applied to the hetero-Michael addition of nitrogen, sulfur and oxygen nucleophiles to α,β-unsaturated ketones under solvent-free conditions. Notably, 1-methylimidazoliump-toluenesulfonic ([Hmim]OTs) was found to be the most efficient catalyst and could realize “homogeneous catalysis, two-phase separation”. Additionally, the catalytic system has wide substrate scope and good to excellent yields (up to 99%) could be obtained at room temperature.