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Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid†
Zhiping Yin,Zechao Wang,Xiao-Feng Wu
Organic & Biomolecular Chemistry Pub Date : 04/30/2018 00:00:00 , DOI:10.1039/C8OB00810H
Abstract

Herein we present a new strategy for the dehydrogenative–decarboxylative coupling of indoles with glyoxylic acid. A broad range of indoles were transformed into the corresponding 3-formylindoles in moderate to good yields and excellent functional group tolerance. Notably, no N-formylation product was detected under our conditions.

Graphical abstract: Selective nickel-catalyzed dehydrogenative–decarboxylative formylation of indoles with glyoxylic acid
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