The rhodium catalyzed three-component reaction of diazoacetates, titanium(iv) alkoxides and aldehydes†
Hui Liu,Zhi-Yong Chen,Wen-Hao Hu,Ai-Qiao Mi
Chemical Communications Pub Date : 04/06/2005 00:00:00 , DOI:10.1039/B502093J
Abstract

The rhodium(II)-catalyzed three-component reaction of diazoacetates, titanium alkoxides and aldehydes is shown to give α-alkoxyl-β-hydroxyl acid derivatives; the novel C–C bond formation reaction is proposed to occur through oxonium ylides derived from diazo compounds and titanium alkoxides, and followed by intermolecular trapping by aldehydes.

Graphical abstract: The rhodium catalyzed three-component reaction of diazoacetates, titanium(iv) alkoxides and aldehydes