Metal–organic polyhedra are a member of metal–organic materials, and are together with metal–organic frameworks utilized as emerging porous platforms for numerous applications in energy- and bio-related sciences. However, metal–organic polyhedra have been significantly underexplored, unlike their metal–organic framework counterparts. In this review, we will cover the topologies and the classification of metal–organic polyhedra and share several suggestions, which might be useful to synthetic chemists regarding the future directions in this rapid-growing field.