An efficient method of palladium-catalyzed direct arylation has been developed for the selective functionalization of the C6 position of 2,4-diarylpyrrolo[2,3-d]pyrimidines. Under optimal conditions, various aryl bromides successfully provided a wide range of 6-arylpyrrolo[2,3-d]pyrimidines.
![Graphical abstract: Access to 6-arylpyrrolo[2,3-d]pyrimidines via a palladium-catalyzed direct C–H arylation reaction](http://hg.y866.cn/compound/lib/scimg/usr/1/C4RA07088G.jpg)
