Scalable, efficient total synthesis of (+)-mupirocin H†,10.1039/C3QO00038A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Scalable, efficient total synthesis of (+)-mupirocin H†

Changgui Zhao,Ziyun Yuan,Yuanyuan Zhang,Bin Ma,Huilin Li,Shouchu Tang,Xingang Xie

Organic Chemistry Frontiers Pub Date : 12/23/2013 00:00:00 , DOI:10.1039/C3QO00038A

Abstract

A scalable, efficient total synthesis of mupirocin H was accomplished in 7 longest linear steps with 39% overall yield. The developed strategy is great progress for the construction of pseudomonic acid analogues and all steps in our strategy could be conducted on a gram scale. The strategy is also suitable for other related molecules.