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Ternary and quaternary phase diagrams: key tools for chiral resolution through solution cocrystallization†
Géraldine Springuel,Laurent Collard,Tom Leyssens
CrystEngComm Pub Date : 08/02/2013 00:00:00 , DOI:10.1039/C3CE41141A
Abstract

The goal of this contribution is to guide the reader through the construction and the understanding of quaternary phase diagrams in the pursuit of optimal conditions for a chiral resolution through cocrystallization in solution. The overall description will be illustrated by experimental results on a system involving RS-2-(2-oxopyrrolidin-1-yl) butanamide as chiral API to be separated, and S-mandelic acid as chiral coformer.

Graphical abstract: Ternary and quaternary phase diagrams: key tools for chiral resolution through solution cocrystallization
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