Total synthesis and absolute structure of N55, a positive modulator of GLP-1 signaling†,10.1039/D0OB01722A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Total synthesis and absolute structure of N55, a positive modulator of GLP-1 signaling†

Nai-Pin Lin,Rong-Jie Chein

Organic & Biomolecular Chemistry Pub Date : 10/21/2020 00:00:00 , DOI:10.1039/D0OB01722A

Abstract

Glucagon-like peptide-1 (GLP-1) signaling is an established therapeutic target for type 2 diabetes mellitus (T2DM). We developed a 7-step synthesis of N55, a positive modulator of GLP-1 signaling isolated from fenugreek (Trigonella foenum-graecum) seeds, with 29% overall yield, and we determined the absolute structure of N55 to be N-((3R,4R,5S)-4,5-dimethyl-2-oxotetrahydrofur-3-yl)linoleic amide.