Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates†,10.1039/C8CC07481J

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Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates†

Shangda Li,Yuzhen Gao,Lei Fu

Chemical Communications Pub Date : 10/22/2018 00:00:00 , DOI:10.1039/C8CC07481J

Abstract

A protocol of Pd(II)-catalyzed, weak bidentate directing group assisted β-C(sp³)–H activation/cross-coupling with organoboron reagents has been achieved, affording arylation of aliphatic acid derivatives that contain α-hydrogen atoms in moderate to good yields. The potential of this method for an asymmetric β-C(sp³)–H arylation via desymmetrization was also presented.