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Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents†
Francesco Messa,Serena Perrone,Martina Capua,Francesco Tolomeo,Luigino Troisi,Vito Capriati,Antonio Salomone
Chemical Communications Pub Date : 06/25/2018 00:00:00 , DOI:10.1039/C8CC03858A
Abstract

A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate scope, and a variety of amides have been synthesized in yields up to 98%.

Graphical abstract: Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents
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