Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation†,10.1039/C9QO01283D

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Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation†

Wei Liu,Hua-Yue Wu,Yun-Bing Zhou,Qiuping Ding,Yiyuan Peng

Organic Chemistry Frontiers Pub Date : 12/12/2019 00:00:00 , DOI:10.1039/C9QO01283D

Abstract

(NH₄)₂S₂O₈-mediated decarboxylative trifluoroalkylation of alkenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid under metal-free conditions has been described. This approach provides a new pathway to directly synthesize a series of CMe₂CF₃-containing chroman-4-ones from simple chemical feedstocks. Particularly, the utility of the method was demonstrated by its application in the synthesis of CMe₂CF₃-derived TRPV1 precursors.