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Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes†
Sudipta Raha Roy,Hendrik Eijsberg,Jeffrey Bruffaerts,Ilan Marek
Chemical Science Pub Date : 08/30/2016 00:00:00 , DOI:10.1039/C6SC02617F
Abstract

The regio- and diastereoselective zirconocene-catalyzed carbomagnesiation of cyclobutenes is herein reported to afford configurationally stable cyclobutylmagnesium species that could subsequently react with a large variety of electrophiles to give polysubstituted cyclobutane species as a single diastereoisomer.

Graphical abstract: Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes
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