Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide†,10.1039/C8RA02511H

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide†

Martin Oliver,Charlène Gadais,Júlia García-Pindado,Meritxell Teixidó,Nathalie Lensen,Grégory Chaume,Thierry Brigaud

RSC Advances Pub Date : 04/18/2018 00:00:00 , DOI:10.1039/C8RA02511H

Abstract

The synthesis of four CF₃-proline analogues of the PLG peptide is reported. Our results show that the incorporation of trifluoromethylated amino acids (Tfm-AAs) at the N-terminal position of a peptide significantly increases its hydrophobicity. In addition, depending on the relative configuration and the position of the CF₃ group, Tfm-AAs can also promote passive diffusion transport.