Centric (P21/n) and non-centric (P21) polymorphic pairs of biologically active 1-(4-fluorophenyl)-6,6-dimethyl-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one crystallized from different solvents have been elucidated via single crystal and powder X-ray diffraction studies, morphological observations and calorimetric measurements. C–H⋯O hydrogen bonding and weak intermolecular C–H⋯π interactions generate distinct packing features in the two forms.
