Mono-acid incorporated calix[4]arene has been successfully established as the catalyst for the synthesis of 8-imino-1-one acridine derivatives obtained by the condensation of enaminoketones and aldehydes (2 : 1 ratio). In this paper, we report the synthesis of a new member of the acridine family, the 8-imino-1-one acridines. A library of these compounds has been synthesized with diversified functionalities using green methodology.