The triisopropylsilyl effect: exceptional Cram-type selectivity in Mukaiyama aldol reactions of a silyl ketene thioacetal
Chemical Communications Pub Date : 01/01/1900 00:00:00 , DOI:10.1039/A804153I
Abstract

The level of 1,2-asymmetric induction in the BF3·OEt2-promoted addition of silyl ketene thioacetals to α-asymmetric aldehydes is affected by the bulk of the silyl group; unprecedented Cram-type selectivity is given by the triisopropylsilyl derivative 8a.