Solid support mediated chemo and regioselective synthesis of 3H-1,5- benzodiazepines from diversely substituted α-oxo ketene dithioacetals†,10.1039/C3RA43347A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Solid support mediated chemo and regioselective synthesis of 3H-1,5- benzodiazepines from diversely substituted α-oxo ketene dithioacetals†

Nutan Sharma,Tejpal Singh Chundawat,Subash Chandra Mohapatra,Sunita Bhagat

RSC Advances Pub Date : 07/23/2013 00:00:00 , DOI:10.1039/C3RA43347A

Abstract

Solvent free, dry media supported synthesis of a series of 4-aryl/heteroaryl-2-methylthio-3H-1,5-benzodiazepines by chemo- and regioselective cyclization of substituted α-oxoketene dithioacetals with o-phenylenediamines is described. The X-ray crystallographic studies confirmed the formation of the cyclized product.