Using experimental and computational approaches to probe an unusual carbon–carbon bond cleavage observed in the synthesis of benzimidazole N-oxides†,10.1039/D0OB01797C

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Using experimental and computational approaches to probe an unusual carbon–carbon bond cleavage observed in the synthesis of benzimidazole N-oxides†

Arturo León Sandoval,Jorge G. Uranga,Elba I. Buján,Nicholas E. Leadbeater

Organic & Biomolecular Chemistry Pub Date : 11/06/2020 00:00:00 , DOI:10.1039/D0OB01797C

Abstract

Experimental and computational studies have been performed in order to investigate an unusual carbon–carbon bond cleavage that occurs in the preparation of certain benzimidazole N-oxides from anilines. The key factor determining the outcome of the reaction was found to be the substituents on the amine functionality of the aniline.