Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system†,10.1039/C2CC33511E

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system†

Stefano D'Errico,Giorgia Oliviero,Jussara Amato,Nicola Borbone,Vincenzo Cerullo,Akseli Hemminki,Vincenzo Piccialli,Sabrina Zaccaria,Luciano Mayol,Gennaro Piccialli

Chemical Communications Pub Date : 07/30/2012 00:00:00 , DOI:10.1039/C2CC33511E

Abstract

A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.