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Stereoselective synthesis of C-glycosides from carboxylic acids: the tandem Tebbe–Claisen approach†
H. Yasmin Godage,David J. Chambers,Graham R. Evans,Antony J. Fairbanks
Organic & Biomolecular Chemistry Pub Date : 08/28/2003 00:00:00 , DOI:10.1039/B306675B
Abstract

A variety of β- or α-C-glycosides may be readily accessed in an entirely stereoselective fashion from esters derived from the reaction of carboxylic acids and 3-hydroxy glycals, by way of a tandem reaction sequence of Tebbe methylenation and Claisen rearrangement. Though of wide scope, for example allowing the synthesis of 1–6 linked C-disaccharides, the methodology does not currently allow the synthesis of C-glycosyl α-amino acids.

Graphical abstract: Stereoselective synthesis of C-glycosides from carboxylic acids: the tandem Tebbe–Claisen approach
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