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Triple molecular target approach to selective melanoma cytotoxicity†
Edward B. Skibo,Akmal Jamil,Brittany Austin,Douglas Hansen,Armand Ghodousi
Organic & Biomolecular Chemistry Pub Date : 01/28/2010 00:00:00 , DOI:10.1039/B920260A
Abstract

Phenylalanine-linked pyrrolo[1,2-a]benzimidazoles were successfully designed to target melanoma cells in vitro. Our design utilised three molecular targets: a phenylalanine pump, the reducing enzyme DT-diaphorase, and IMP dehydrogenase. We describe the synthesis of these compounds as well as the results of in vitro, in vivo, and QSAR studies.

Graphical abstract: Triple molecular target approach to selective melanoma cytotoxicity
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