Structure inducing ionic liquids—enhancement of alpha helicity in the Abeta(1–40) peptide from Alzheimer's disease†,10.1039/C1CC10377F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Structure inducing ionic liquids—enhancement of alpha helicity in the Abeta(1–40) peptide from Alzheimer's disease†

Natalie Debeljuh,Colin J. Barrow,Luke Henderson,Nolene Byrne

Chemical Communications Pub Date : 05/06/2011 00:00:00 , DOI:10.1039/C1CC10377F

Abstract

We have studied the impact of ionic liquid solvents on the structure of the Abeta(1–40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1–40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.