Stereoselective synthesis of triarylethylenes via copper–palladium catalyzed decarboxylative cross-coupling: synthesis of (Z)-tamoxifen†,10.1039/C4CC03752A

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Stereoselective synthesis of triarylethylenes via copper–palladium catalyzed decarboxylative cross-coupling: synthesis of (Z)-tamoxifen†

Gérard Cahiez,Maël Poizat

Chemical Communications Pub Date : 06/19/2014 00:00:00 , DOI:10.1039/C4CC03752A

Abstract

The first Cu/Pd-catalyzed decarboxylative cross-coupling of 3,3-diarylacrylic acids with aryl bromides is described. Triarylethylenes were obtained in high yields with excellent stereoselectivities. This methodology was successfully applied to the stereoselective synthesis of (Z)-tamoxifen.